It’s tough to pinpoint a single individual as the “leading” longevity researcher, as the field is highly interdisciplinary, and numerous scientists and researchers have made significant contributions. However, several scientists and institutions have been prominent in longevity research: Dr. David
The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule
In June 2018, the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases and added aging for the first time. The classification of aging as a disease paves the way for new research into novel therapeutics to
Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease
Abstract Leigh syndrome is a mitochondrial disease characterized by neurological disorders, metabolic abnormalities, and premature death. There is no cure for Leigh syndrome; therefore, new therapeutic targets are urgently needed. In Ndufs4-KO mice, a mouse model of Leigh syndrome, we
The Biology of Slowing & Reversing Aging | Huberman Lab Podcast 52
In this episode, Dr. Andrew Huberman is joined by Dr. David Sinclair, a tenured Professor of Genetics at Harvard Medical School and an expert researcher in longevity. Dr. Sinclair is also the author of Lifespan: Why We Age & Why
The Interplay Between Aging and Disease
Dr. Felipe Sierra discusses the concept of geroscience, which focuses on the relationship between aging and age-related diseases. He emphasizes the significant increase in human lifespan but also highlights the problem of increased health issues in older individuals. Traditional medicine
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
Highlights •NMN suppresses age-associated body weight gain and enhances energy metabolism •NMN improves insulin sensitivity, eye function, and other features with no toxicity •NMN prevents age-associated gene expression changes in a tissue-specific manner •NMN is an effective anti-aging intervention that
NAD+ in Aging: The Roles of NR and NMN
Rhonda delves into NAD+: its importance for aging, its decline as we age, and popular NAD+ enhancers like nicotinamide riboside and nicotinamide mononucleotide. NAD+ is vital for survival, with small dietary contributions, but the body mainly recycles it. Everyday life